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The reason why you don't know what it is is because western medicine

largely discounts it. I discounted it for a long time too and then

discovered that all of my problems improved and sometimes even went

away completely for a time when I stopped eating sugar and carbs.

This is a diet in the extreme and isn't healthy for the long term. I

had to cut out all fruit and carbohydrates in order to even function.

Candida is a fungus that naturally lives in the intestine and feeds

on sugar - has some enzymes of it's own to break down carbohydrates

into sugar. See wikipedia.org for a better definition. There are

many different strains of candida all with varying properties degrees

of virilence. For me it seemed like everything changed overnight and

I was no longer able to eat normally. I stongly believe that I had a

strain that was toucher and heartier that just the ordinary endogenous

Candida Ablicans.

Another problem is that western medicine rarely tests Candida since it

is widely regarded as " normal " in small quantities therefor, it is

difficult to know what strain of candida you have and whether this is

the cause of your problems. It's very frustrating. I also

discovered that my problem was fungus related when I found - by trial

and error - that no drug woul control my symptoms other than anti

fungals.

Candida is getting a little more attention since it is a very common

secondary infection in AIDS patients but again, western docs assume

that you cannot have a candida infection with some other immune

supression problem like AIDS. AIDS has also made the problem of

Candida, cryptosporidium and other fungal pathogens more prevelent

amoung the population at large.

> > LDN is not for Candida. You need some pro-biotics for that.

> Acidophillus and

> > Olive leaf extract are excellent.

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I'm with you Tom, I do olive, not coconut oil (but I've heard from Dr. Weil that coconut is also very good) and a good 1/2 of walnuts per day. Sprinkle them in your salads and cereal they are a wonderful nut in many ways! It helps being nutty!!

From: Bayuk [mailto:tbayuk@...] Sent: Wednesday, August 04, 2004 5:17 PMmscured ; MS-Christians ; MS_Community ; MSersLife ; MSfriends ; MSViews_Multiple_Sclerosis ; low dose naltrexone ; A Home away from Home a MS Support BoardSubject: [low dose naltrexone] candida

Hi All, In my opinion, the same can be accomplished with coconut oil, colloidal silver, eating 1/2 cup of walnuts daily and taking acidolophis. I'm just starting so I'll keep you posted. Regards, Tom Fatigue in Multiple Sclerosis by Perlmutter, M.D.

Perlmutter, M.D., is a board-certified neurologist practicing neurology and preventive medicine in Naples, Florida. He hosts the weekly, prime-time television program LifeGuide and is the author of LifeGuide: Your Guide to a Longer and Healthier Life. Dr. Perlmutter can be reached at (239) 649-7400.

Recent advances in the understanding of the pathophysiology of multiple sclerosis (MS) are providing fertile ground for the development of unique treatment approaches. Unfortunately, an air of pessimism remains pervasive in a large segment of MS patients as well as clinicians dealing with this entity. Indeed, the historical descriptions of this disease have been filled with bleak commentary. As Godfried Sonderdank, Court Physician of Schiedam, Holland, reported in the 14th century when describing a disease now thought to represent MS with slowly evolving weakness of three extremities, dysphagia, a variety of sensory disturbances, as well as bilateral visual symptomatology: "Believe me, there is no cure for this illness. It comes directly from God. Even Hippocrates and Gallenus would not be of any help here."1

Generalized fatigue seems to be one of the most common complaints of patients with multiple sclerosis. Yet the importance of fatigue in terms of compromising the quality of life in MS patients may not be fully appreciated by healthcare practitioners. When recognized, treatment options are generally few and only minimally effective.

In a recent survey of neurologists it was found that most favored research directed toward understanding the cause of fatigue in multiple sclerosis, while one-third said research should be focused on the development of new medications.2 Medicines most commonly used to treat fatigue in multiple sclerosis include Pemoline and Amantadine.

A recent study demonstrated that in 46 MS patients with disabling fatigue, Pemoline was preferred in 51.2% compared to 46.3% who preferred placebo. Detracting side effects of Pemoline in this study included insomnia, anorexia, headache, irritability, dizziness, and nausea.3 Other investigators have reported a 31% benefit in the treatment of MS-associated fatigue using Amantadine.4 Side effects noted with Amantadine have included nausea, dizziness, light-headedness, insomnia, depression, irritability, hallucinations, and confusion.

With the destruction of myelin in MS, nerve conduction in the demyelinated fibers is slowed, becomes temperature sensitive, and then fatigues rapidly. Myelin, however, may regenerate, but the regenerated myelin is usually ineffective with respect to function.

Recently, Dutch investigators have studied the use of 4-aminopyridine (4-AP) in an attempt to improve multiple sclerosis symptoms.5 4-AP is a potassium blocking chemical which has been demonstrated to increase nerve conduction through areas of demyelinization. The study evaluated 70 patients with clinically definite MS ranging in age from 23 to 68 years. Subjects were evaluated using a standardized disability scale (Kurtzke) at 2, 6, 12, 14, 18 and 24 weeks with monitoring of blood levels of 4-AP. The most significant side effect was a one percent incidence of epileptic seizures. The study group clearly demonstrated improvements when compared to the placebo group with respect to various motor skills including ambulatory function. The main emphasis until now with respect to developing treatment strategies for multiple sclerosis have been either anti-inflammatory or immunosuppressive, designed to limit the extent of an acute attack or prevent exacerbations and progression of the disease, respectively. 4-Aminopyridine, however, approaches MS treatment in a different light, attempting to reestablish function through demyelinative nerve pathways whose function is compromised. 4-AP is inexpensive, available, and thus far seems to demonstrate only minimal side effects. Finally, since fatigue in MS has been thought by some investigators to represent a consequence of defective nerve transmission, these use of 4-AP in this scenario seems quite rational. Autoimmune Disease and Candida The possible link between various auto immune diseases and infection with the yeast Candida albicans has been described by well-respected researchers over the past two decades. As Trowbridge recently stated when discussing autoimmune diseases, "They appear to be among the growing number of otherwise unrelated disorders partially caused by inflammation and destruction of cells, tissues and organs by the body's own antibodies (autoantibodies). These disorders belong to the autoimmune classification of diseases.

"Science has not explained why the body should lose the ability to distinguish between substances that are 'self' and those that are 'nonself.' An accumulating stack of evidence is pointing the finger of suspicion directly at Candida albicans, as well as at other parasites or infections. How the yeast organism fosters a compromise of normal immune function is the subject of investigation and much speculation by the worldwide scientific and clinical communities."6 Because of the frequent association of candidiasis with generalized fatigue and the autoimmune nature of multiple sclerosis, we evaluated ten adult MS patients for the presence of Candida immune complexes and Candida antibodies. The diagnosis of MS was confirmed by history, physical examination, and magnetic resonance brain scanning in these patients. Quantitative serum levels of Candida IgG, IgA, IgM, and immune complexes were assayed using an enzyme-linked immunoassay. (Antibody Assay Laboratories, Santa Ana, California). Candida immune complexes contain IgG Candida antibodies, Candida antigen, and fragments of complement. Immune complexes are present in direct proportion to the Candida load. Candida immune complexes are perhaps the most sensitive test for active Candida-related illness. Candida antibodies (IgM) are transiently elevated in acute infections. IgA antibodies are elevated in surface infections such as the mucosa of the mouth, gastrointestinal tract, and vagina or urethra. IgG antibodies are present in most adults and may persist long after the infection has been cured; therefore, elevated levels may simply indicate past infection. Table 1 summarizes our findings. These data indicate elevated levels of Candida immune complexes in half of the subjects studied. In addition, Candida antibodies were frequently elevated as well with elevated levels of IgG seen in 40%, IgA in 40%, and IgM in 30%.

Table 1

Patient Number

1

2

3

4

5

6

7

8

9

10

Candida Immune Complexes(0-1-0.9)

1.0

0.1

1.0

0.1

0.1

0.2

0.1

1.0

1.0

1.7

Candida IgG AB's (0-10)

12.0

13.0

3.0

11.0

7.0

5.0

0.0

7.5

12.0

5.0

Candida IgA AB's (0-10)

19.0

11.0

0.0

5.0

9.0

4.0

2.0

13.0

31.0

8.0

Candida IgM AB's (0-10)

9.0

14.1

3.0

11.0

7.0

3.0

6.0

5.0

9.0

14.0

Because of the high frequency of gut dysbiosis (a state of disordered bowel flora ecology) in various autoimmune diseases as well as chronic fatigue immune deficiency syndrome (CFIDS), we performed stool analysis on nine adult patients with MS diagnosed by history, physical examination, and magnetic resonance brain scanning. We utilized a Comprehensive Digestive Stool Analysis (Great Smokies Diagnostic Laboratories, Asheville, North Carolina). This study provides a variety of useful data including digestive markers (digestion and absorption), metabolic markers (balance of a variety of short chain fatty acids), bacteriology including normal flora, imbalanced flora, and possible pathogens, ratio of gram positive to gram negative organisms, mycology evaluation including normal organisms and possible pathogens, macroscopic evaluation, as well as a dysbiosis index. In this study we were most interested in mycology, lactobacillus count, and dysbiosis index.

The results are summarized in Table 2. This study reveals the presence of Candida albicans in the stool specimens of one-third of the patients studied. The dysbiosis index was elevated in all patients and the lactobacillus count was depressed in all patients as well.

Table 2 Comprehensive Digestive Stool Analysis

Patient Number

2

3

4

5

6

7

8

9

10

Mycology

None

None

None

C.Alb2+

None

None

None

C.Alb 1+

C.Alb1+

Lactobacillus (2+ or greater)

0

2+

0

0

0

0

0

0

1+

Dysbiosis Index (0-3)

10

6

8

6

6

16

6

12

8

The relationship between Candida activity and chronic fatigue has certainly been well-described by various authors. We believe that these data provide compelling evidence that candidiasis may, at the very least, be a frequent occurrence in patients with multiple sclerosis.

In addition, these data seem to indicate that intestinal dysbiosis may be common in MS patients. Dysbiosis is certainly well-recognized in patients suffering from inflammatory bowel disease (also an autoimmune phenomenon), and it is certainly well known that inflammatory bowel disease is often associated with extra-intestinal inflammatory manifestations such as arthritis, iritis/uveitis, and others. We believe, and these data suggest, that there is a strong likelihood that a relationship may exist between intestinal dysbiosis and multiple sclerosis. In a recent report in The Lancet,7 the frequency of white-matter lesions in 72 consecutive patients with inflammatory bowel disease, 48 with Crohn's disease, and 24 with ulcerative colitis was investigated. Magnetic resonance imaging studies of the brain were performed on the study group and compared to an age-matched healthy control population. This study found hyperintense focal white-matter lesions ranging from 2-8 mm. in diameter in 20 of the 48 patients with Crohn's disease (42%), in 11 of 24 patients with ulcerative colitis (46%), and in 8 of 50 healthy volunteers (16%).

Interestingly, the authors' report: "The frequency of focal white-matter lesions in patients with inflammatory bowel disease is almost as high as that in patients with multiple sclerosis (65%)."

We now routinely perform serum analysis for Candida immune complexes and Candida antibodies (IgG, IgM, and IgA) as well as a Comprehensive Digestive Stool Analysis on our multiple sclerosis patients.

MS patients with findings indicative of active candidiasis are generally treated with an antifungal agent, typically fluconazole (Diflucan), in dosages ranging from 100 mg. every other day to 150 mg. per day depending on patient size and disease activity. Typically, fluconazole is continued for four to six weeks or even longer depending on response. Midway through treatment we typically assess liver transaminase function. We utilize a low carbohydrate diet as popularized by Dr. Crook.8

Patients demonstrating an elevated dysbiosis index with deficiencies of lactobacillus are generally treated initially utilizing Ultra-Flora Plus (fructo-oligosaccharides, concentrate of globulin protein from whey, Lactobacillus acidophilus, NCFM, Bifido bacterium infantis [A]), which is a nutritional support program designed for patient suffering from dysbiosis. This program is utilized along with a diet eliminating caffeine, alcohol, wheat, and dairy products.

In addition, it is critically important to recognize the importance of vitamin B-12 metabolism in the pathogenesis of multiple sclerosis as we described in a previous edition of TLfD (April 1993, pp. 304-305). Although we typically continue to assess vitamin B-12 levels, we have been more impressed of late with the usefulness of urine methylmalonic acid in providing more relevant information as to B-12 status.

We generally supplement our multiple sclerosis patients with high dosage vitamin B-12 given by IM injection.

Typically, we will begin treatment with 1,000 mcg. of vitamin B-12 administered IM on a daily basis for a two-week period of time followed by a weekly injection for the following four to six weeks and then continue with 1,000 mcg. IM on a monthly basis. We are frequently able to instruct our patients in self-administration of B-12, thus minimizing inconvenience and cost.

This report demonstrates a significantly increased incidence of elevated Candida-related markers in patients with multiple sclerosis. Our success in reducing fatigue in multiple sclerosis with treatments designed specifically to reduce Candida activity lends further support for the suggested relationship between MS related fatigue and Candida activity.

Further, we suggest that intestinal dysbiosis may play a pivotal role with respect to the actual pathogenesis of multiple sclerosis as an autoimmune disease entity.

We gratefully acknowledge the generous assistance and cooperation of Antibody Assay Laboratories, (1715 East Wilshire, #715, Santa Ana, California 92705, Telephone: 714-972-9979) in providing serum evaluations of Candida immune complexes and antibody levels in our patients as well as Great Smokies Diagnostic Laboratory (18A Regent Park Boulevard, Asheville, North Carolina 28806, Telephone: 704-253-0621) for providing the Comprehensive Stool Analysis for our patients in this study.

References:

1. Medaer, R: Does the History of Multiple Sclerosis Go Back as Far as the Fourteenth Century? Acta, Neurol. Scand., 60:189-192, 1979.

2. MS Quarterly Report Volume 12, #4, February 1994, page 9.

3. Weinshenker, B.G., et at., A Double-Blind, Randomized, Cross-Over Trial of Pemoline in Fatigue Associated with Multiple Sclerosis, Neurology 1992: 4268-1471.

4. MS Quarterly Report Volume 13, #4, December 1994, 4-5.

5. Van Dieman, et al., Effect of 4-Aminopyridine on Clinical Science in Multiple Science: A Randomized Placebo-Controlled, Double-Blind, Cross-Over Study. ls of Neurology 1992:32:123-130.

6. Trowbridge, M.D., and , Morton D.P.M., The Yeast Syndrome, Bantam Books, New York, 1988, Page 35.

7. Geissler, A., et al., Focal White-Matter Lesions In Brain of Patients With Inflammatory Bowel Disease, Lancet Vol. 345, 1995, 897-8.

8. Crook, M.D., The Yeast Connection, Vintage Books, New York, 1986.

Reference A:

Metagenics, 4403 Vineland Road, Suite B12, Orlando, FL 32811. Telephone: 800-647-6100

Return to Perlmutter Home Page.

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Guest guest

,

Being "Nutty" has probably given me 10 or 5 more years, LOL.

Regards,

Tom

----- Original Message -----

From: Baden

low dose naltrexone

Sent: Thursday, August 05, 2004 8:49 AM

Subject: RE: [low dose naltrexone] candida

I'm with you Tom, I do olive, not coconut oil (but I've heard from Dr. Weil that coconut is also very good) and a good 1/2 of walnuts per day. Sprinkle them in your salads and cereal they are a wonderful nut in many ways! It helps being nutty!!

From: Bayuk [mailto:tbayuk@...] Sent: Wednesday, August 04, 2004 5:17 PMmscured ; MS-Christians ; MS_Community ; MSersLife ; MSfriends ; MSViews_Multiple_Sclerosis ; low dose naltrexone ; A Home away from Home a MS Support BoardSubject: [low dose naltrexone] candida

Hi All, In my opinion, the same can be accomplished with coconut oil, colloidal silver, eating 1/2 cup of walnuts daily and taking acidolophis. I'm just starting so I'll keep you posted. Regards, Tom Fatigue in Multiple Sclerosis by Perlmutter, M.D.

Perlmutter, M.D., is a board-certified neurologist practicing neurology and preventive medicine in Naples, Florida. He hosts the weekly, prime-time television program LifeGuide and is the author of LifeGuide: Your Guide to a Longer and Healthier Life. Dr. Perlmutter can be reached at (239) 649-7400.

Recent advances in the understanding of the pathophysiology of multiple sclerosis (MS) are providing fertile ground for the development of unique treatment approaches. Unfortunately, an air of pessimism remains pervasive in a large segment of MS patients as well as clinicians dealing with this entity. Indeed, the historical descriptions of this disease have been filled with bleak commentary. As Godfried Sonderdank, Court Physician of Schiedam, Holland, reported in the 14th century when describing a disease now thought to represent MS with slowly evolving weakness of three extremities, dysphagia, a variety of sensory disturbances, as well as bilateral visual symptomatology: "Believe me, there is no cure for this illness. It comes directly from God. Even Hippocrates and Gallenus would not be of any help here."1

Generalized fatigue seems to be one of the most common complaints of patients with multiple sclerosis. Yet the importance of fatigue in terms of compromising the quality of life in MS patients may not be fully appreciated by healthcare practitioners. When recognized, treatment options are generally few and only minimally effective.

In a recent survey of neurologists it was found that most favored research directed toward understanding the cause of fatigue in multiple sclerosis, while one-third said research should be focused on the development of new medications.2 Medicines most commonly used to treat fatigue in multiple sclerosis include Pemoline and Amantadine.

A recent study demonstrated that in 46 MS patients with disabling fatigue, Pemoline was preferred in 51.2% compared to 46.3% who preferred placebo. Detracting side effects of Pemoline in this study included insomnia, anorexia, headache, irritability, dizziness, and nausea.3 Other investigators have reported a 31% benefit in the treatment of MS-associated fatigue using Amantadine.4 Side effects noted with Amantadine have included nausea, dizziness, light-headedness, insomnia, depression, irritability, hallucinations, and confusion.

With the destruction of myelin in MS, nerve conduction in the demyelinated fibers is slowed, becomes temperature sensitive, and then fatigues rapidly. Myelin, however, may regenerate, but the regenerated myelin is usually ineffective with respect to function.

Recently, Dutch investigators have studied the use of 4-aminopyridine (4-AP) in an attempt to improve multiple sclerosis symptoms.5 4-AP is a potassium blocking chemical which has been demonstrated to increase nerve conduction through areas of demyelinization. The study evaluated 70 patients with clinically definite MS ranging in age from 23 to 68 years. Subjects were evaluated using a standardized disability scale (Kurtzke) at 2, 6, 12, 14, 18 and 24 weeks with monitoring of blood levels of 4-AP. The most significant side effect was a one percent incidence of epileptic seizures. The study group clearly demonstrated improvements when compared to the placebo group with respect to various motor skills including ambulatory function. The main emphasis until now with respect to developing treatment strategies for multiple sclerosis have been either anti-inflammatory or immunosuppressive, designed to limit the extent of an acute attack or prevent exacerbations and progression of the disease, respectively. 4-Aminopyridine, however, approaches MS treatment in a different light, attempting to reestablish function through demyelinative nerve pathways whose function is compromised. 4-AP is inexpensive, available, and thus far seems to demonstrate only minimal side effects. Finally, since fatigue in MS has been thought by some investigators to represent a consequence of defective nerve transmission, these use of 4-AP in this scenario seems quite rational. Autoimmune Disease and Candida The possible link between various auto immune diseases and infection with the yeast Candida albicans has been described by well-respected researchers over the past two decades. As Trowbridge recently stated when discussing autoimmune diseases, "They appear to be among the growing number of otherwise unrelated disorders partially caused by inflammation and destruction of cells, tissues and organs by the body's own antibodies (autoantibodies). These disorders belong to the autoimmune classification of diseases.

"Science has not explained why the body should lose the ability to distinguish between substances that are 'self' and those that are 'nonself.' An accumulating stack of evidence is pointing the finger of suspicion directly at Candida albicans, as well as at other parasites or infections. How the yeast organism fosters a compromise of normal immune function is the subject of investigation and much speculation by the worldwide scientific and clinical communities."6 Because of the frequent association of candidiasis with generalized fatigue and the autoimmune nature of multiple sclerosis, we evaluated ten adult MS patients for the presence of Candida immune complexes and Candida antibodies. The diagnosis of MS was confirmed by history, physical examination, and magnetic resonance brain scanning in these patients. Quantitative serum levels of Candida IgG, IgA, IgM, and immune complexes were assayed using an enzyme-linked immunoassay. (Antibody Assay Laboratories, Santa Ana, California). Candida immune complexes contain IgG Candida antibodies, Candida antigen, and fragments of complement. Immune complexes are present in direct proportion to the Candida load. Candida immune complexes are perhaps the most sensitive test for active Candida-related illness. Candida antibodies (IgM) are transiently elevated in acute infections. IgA antibodies are elevated in surface infections such as the mucosa of the mouth, gastrointestinal tract, and vagina or urethra. IgG antibodies are present in most adults and may persist long after the infection has been cured; therefore, elevated levels may simply indicate past infection. Table 1 summarizes our findings. These data indicate elevated levels of Candida immune complexes in half of the subjects studied. In addition, Candida antibodies were frequently elevated as well with elevated levels of IgG seen in 40%, IgA in 40%, and IgM in 30%.

Table 1

Patient Number

1

2

3

4

5

6

7

8

9

10

Candida Immune Complexes(0-1-0.9)

1.0

0.1

1.0

0.1

0.1

0.2

0.1

1.0

1.0

1.7

Candida IgG AB's (0-10)

12.0

13.0

3.0

11.0

7.0

5.0

0.0

7.5

12.0

5.0

Candida IgA AB's (0-10)

19.0

11.0

0.0

5.0

9.0

4.0

2.0

13.0

31.0

8.0

Candida IgM AB's (0-10)

9.0

14.1

3.0

11.0

7.0

3.0

6.0

5.0

9.0

14.0

Because of the high frequency of gut dysbiosis (a state of disordered bowel flora ecology) in various autoimmune diseases as well as chronic fatigue immune deficiency syndrome (CFIDS), we performed stool analysis on nine adult patients with MS diagnosed by history, physical examination, and magnetic resonance brain scanning. We utilized a Comprehensive Digestive Stool Analysis (Great Smokies Diagnostic Laboratories, Asheville, North Carolina). This study provides a variety of useful data including digestive markers (digestion and absorption), metabolic markers (balance of a variety of short chain fatty acids), bacteriology including normal flora, imbalanced flora, and possible pathogens, ratio of gram positive to gram negative organisms, mycology evaluation including normal organisms and possible pathogens, macroscopic evaluation, as well as a dysbiosis index. In this study we were most interested in mycology, lactobacillus count, and dysbiosis index.

The results are summarized in Table 2. This study reveals the presence of Candida albicans in the stool specimens of one-third of the patients studied. The dysbiosis index was elevated in all patients and the lactobacillus count was depressed in all patients as well.

Table 2 Comprehensive Digestive Stool Analysis

Patient Number

2

3

4

5

6

7

8

9

10

Mycology

None

None

None

C.Alb2+

None

None

None

C.Alb 1+

C.Alb1+

Lactobacillus (2+ or greater)

0

2+

0

0

0

0

0

0

1+

Dysbiosis Index (0-3)

10

6

8

6

6

16

6

12

8

The relationship between Candida activity and chronic fatigue has certainly been well-described by various authors. We believe that these data provide compelling evidence that candidiasis may, at the very least, be a frequent occurrence in patients with multiple sclerosis.

In addition, these data seem to indicate that intestinal dysbiosis may be common in MS patients. Dysbiosis is certainly well-recognized in patients suffering from inflammatory bowel disease (also an autoimmune phenomenon), and it is certainly well known that inflammatory bowel disease is often associated with extra-intestinal inflammatory manifestations such as arthritis, iritis/uveitis, and others. We believe, and these data suggest, that there is a strong likelihood that a relationship may exist between intestinal dysbiosis and multiple sclerosis. In a recent report in The Lancet,7 the frequency of white-matter lesions in 72 consecutive patients with inflammatory bowel disease, 48 with Crohn's disease, and 24 with ulcerative colitis was investigated. Magnetic resonance imaging studies of the brain were performed on the study group and compared to an age-matched healthy control population. This study found hyperintense focal white-matter lesions ranging from 2-8 mm. in diameter in 20 of the 48 patients with Crohn's disease (42%), in 11 of 24 patients with ulcerative colitis (46%), and in 8 of 50 healthy volunteers (16%).

Interestingly, the authors' report: "The frequency of focal white-matter lesions in patients with inflammatory bowel disease is almost as high as that in patients with multiple sclerosis (65%)."

We now routinely perform serum analysis for Candida immune complexes and Candida antibodies (IgG, IgM, and IgA) as well as a Comprehensive Digestive Stool Analysis on our multiple sclerosis patients.

MS patients with findings indicative of active candidiasis are generally treated with an antifungal agent, typically fluconazole (Diflucan), in dosages ranging from 100 mg. every other day to 150 mg. per day depending on patient size and disease activity. Typically, fluconazole is continued for four to six weeks or even longer depending on response. Midway through treatment we typically assess liver transaminase function. We utilize a low carbohydrate diet as popularized by Dr. Crook.8

Patients demonstrating an elevated dysbiosis index with deficiencies of lactobacillus are generally treated initially utilizing Ultra-Flora Plus (fructo-oligosaccharides, concentrate of globulin protein from whey, Lactobacillus acidophilus, NCFM, Bifido bacterium infantis [A]), which is a nutritional support program designed for patient suffering from dysbiosis. This program is utilized along with a diet eliminating caffeine, alcohol, wheat, and dairy products.

In addition, it is critically important to recognize the importance of vitamin B-12 metabolism in the pathogenesis of multiple sclerosis as we described in a previous edition of TLfD (April 1993, pp. 304-305). Although we typically continue to assess vitamin B-12 levels, we have been more impressed of late with the usefulness of urine methylmalonic acid in providing more relevant information as to B-12 status.

We generally supplement our multiple sclerosis patients with high dosage vitamin B-12 given by IM injection.

Typically, we will begin treatment with 1,000 mcg. of vitamin B-12 administered IM on a daily basis for a two-week period of time followed by a weekly injection for the following four to six weeks and then continue with 1,000 mcg. IM on a monthly basis. We are frequently able to instruct our patients in self-administration of B-12, thus minimizing inconvenience and cost.

This report demonstrates a significantly increased incidence of elevated Candida-related markers in patients with multiple sclerosis. Our success in reducing fatigue in multiple sclerosis with treatments designed specifically to reduce Candida activity lends further support for the suggested relationship between MS related fatigue and Candida activity.

Further, we suggest that intestinal dysbiosis may play a pivotal role with respect to the actual pathogenesis of multiple sclerosis as an autoimmune disease entity.

We gratefully acknowledge the generous assistance and cooperation of Antibody Assay Laboratories, (1715 East Wilshire, #715, Santa Ana, California 92705, Telephone: 714-972-9979) in providing serum evaluations of Candida immune complexes and antibody levels in our patients as well as Great Smokies Diagnostic Laboratory (18A Regent Park Boulevard, Asheville, North Carolina 28806, Telephone: 704-253-0621) for providing the Comprehensive Stool Analysis for our patients in this study.

References:

1. Medaer, R: Does the History of Multiple Sclerosis Go Back as Far as the Fourteenth Century? Acta, Neurol. Scand., 60:189-192, 1979.

2. MS Quarterly Report Volume 12, #4, February 1994, page 9.

3. Weinshenker, B.G., et at., A Double-Blind, Randomized, Cross-Over Trial of Pemoline in Fatigue Associated with Multiple Sclerosis, Neurology 1992: 4268-1471.

4. MS Quarterly Report Volume 13, #4, December 1994, 4-5.

5. Van Dieman, et al., Effect of 4-Aminopyridine on Clinical Science in Multiple Science: A Randomized Placebo-Controlled, Double-Blind, Cross-Over Study. ls of Neurology 1992:32:123-130.

6. Trowbridge, M.D., and , Morton D.P.M., The Yeast Syndrome, Bantam Books, New York, 1988, Page 35.

7. Geissler, A., et al., Focal White-Matter Lesions In Brain of Patients With Inflammatory Bowel Disease, Lancet Vol. 345, 1995, 897-8.

8. Crook, M.D., The Yeast Connection, Vintage Books, New York, 1986.

Reference A:

Metagenics, 4403 Vineland Road, Suite B12, Orlando, FL 32811. Telephone: 800-647-6100

Return to Perlmutter Home Page.

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Share on other sites

  • 1 year later...

Hey all,

We have a friend (our kids go to school together) that knows that we are into natural methods of health who has, as she says, candida proplems. Constan, chronic diahrea (sp?), etc. Her doctor, an ancient old man who practices TCM, says it is candida and is working with her on it. But she has asked us if we knew of any cleanse or some such that would help. He gave her a diet that he says will help, but will take a minimum of a year to be effective. So I'm coming to y'all. Any ideas? I checked the files and archives, found some good info, but am looking for more personal stuff. What people have done, how it worked for them, that sort of thing.

Thanks in advance

Peace, love, laughter

“When you laugh, be sure to laugh at what people do and not at what people are.”

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Heck, ... have her start on veggie juice cleanses or even lemon water cleanses.. These mini cleanses will help and also change of diet definitely... but you know that.. Suzi <deuteronomy2929@...> wrote: Hey all, We have a friend (our kids go to school together) that knows that we are into natural methods of health who has, as she says, candida proplems. Constan, chronic diahrea (sp?), etc. Her doctor, an ancient old man who practices TCM, says it is candida and is working with her on it. But she has asked us if we knew of any cleanse or some such that would help. He gave her a diet that he says will help, but will take a minimum of a year to be effective. So I'm coming to y'all. Any ideas? I checked the files and archives, found some good info, but am looking for more personal stuff. What people have

done, how it worked for them, that sort of thing.

FareChase - Search multiple travel sites in one click.

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I was thinking of a juice cleanse, didn't think of the lemon water cleanse. Her diet is okay, but not great. Standard American Diet basically, with very little meat.

Thanks, Suzi.

Peace, love, laughter

"Pooh," said Piglet reproachfully, "haven't you been listening to what Rabbit was saying?" "I listened, but I had a small piece of fluff in my ear. Could you say it again, please, Rabbit?" Rabbit never minded saying things again, so he asked where he should begin from; and when Pooh had said from the moment when the fluff got in his ear, and Rabbit had asked when that was, and Pooh had said he didn't know because he hadn't heard properly, Piglet settled it all by explaining.Suzanne <suziesgoats@...> wrote:

Heck, ... have her start on veggie juice cleanses or even lemon water cleanses.. These mini cleanses will help and also change of diet definitely... but you know that..

Suzi

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START plugging raw and super tonic.... <deuteronomy2929@...> wrote: I was thinking of a juice cleanse, didn't think of the lemon water cleanse. Her diet is okay, but not great. Standard American Diet basically, with very little meat. Thanks, Suzi.

Suzi

What is a weed? A plant whose virtues have not yet been discovered.

health/

www.onegrp.com/?mamanott organic cosmetics

http://suziesgoats.wholefoodfarmacy.com/

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Hey -- I'm just watching a School of Natural Healing video, by

, as

I'm reading through email, and on the " Super Immunity " tape he addresses

candida.

Here's some of what he says (some pretty basic, and you might already know, but

I'll include

it for those who don't.)

Candida is necessary in our intestines to break down sugar and alcohol. When we

use antibiotics

(including heavy metals, like colloidal silver, mercury) those wipe out all the

good bacteria, leaving the

candida all kinds of room to take over. The candida lives on sugar and alcohol

-- if you don't have

a good diet, candida could just continue to over-grow, until it eats holes right

through the

intestinal walls and get into the blood stream, becoming systemic. A candida

overgrowth can

mimic ANY disease, and be difficult to diagnose.

To restablish the good flora, avoid (obviously) sugar and alcohol, and also

foods that quickly turn

into sugar, like potatoes, white rice, dairy products (REAL yogurt -- not the

store bought -- might

be okay).

Suggested candida diet is brown rice and vegies -- complex carbs easily broken

down by the body.

Fermented foods re-establish the friendly flora -- eat sauerkraut, kimchi,

rejuvalac, raw apple cider vinegar.

Extra B vitamins, maybe in the form of nutritional yeast. Eat organic produce

-- they have beneficial flora on their

skins, where most commercial produce do not because of pesticides and other

treatments.

Additionally, he said all chronic fatigue patients have candida problems (it

typically follows

a candida overgrowth). I thought that was very interesting. So re-establish

those friendly bacteria and you're on your way to curing or preventing that

problem too.

(Since fibromyalgia is similar to CF, I thought this might also be helpful

information

for with her fibro problem, too.)

In case anyone's interested, these School of Natural Healing videos have great

information; I've been

picking them up off of ebay when the prices are right. They're offered there

frequently.

M

>We have a friend (our kids go to school together) that knows that we are into

natural methods of health who has, as she says,

candida proplems. Constan, chronic diahrea (sp?), etc. Her doctor, an ancient

old man who practices TCM, says it is candida and is

working with her on it. But she has asked us if we knew of any cleanse or some

such that would help. He gave her a diet that he says

will help, but will take a minimum of a year to be effective. So I'm coming to

y'all. Any ideas? I checked the files and archives, found

some good info, but am looking for more personal stuff. What people have done,

how it worked for them, that sort of thing.

>

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Hi ,

Great info! I'm printing it out now, and bringing it and some other stuff I have to our friend. We pick up our kids at the same time and usually sit and talk for about a half hour. I'mgoing to invite her to this list too.

Thanks again for the great info!!

Peace, love, laughter

“We have to laugh. Because laughter, we already know, is the first evidence of freedom.”knmo <knmo@...> wrote:

Hey -- I'm just watching a School of Natural Healing video, by , asI'm reading through email, and on the "Super Immunity" tape he addresses candida.

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I would avoid the nutritional yeast... even though everything you read talks about how good it is... it IS processed... and anything processed is "dead" food. and since she is trying to get rid of the candida, I would avoid this one for now. Suziknmo <knmo@...> wrote: Extra B vitamins, maybe in the form of nutritional yeast.

Suzi

What is a weed? A plant whose virtues have not yet been discovered.

health/

www.onegrp.com/?mamanott organic cosmetics

http://suziesgoats.wholefoodfarmacy.com/

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  • 1 year later...

Hi Tara,

There is a very good email list dedicated to candida yeast at:

http://catalist.lsoft.com/scripts/wl.exe?SL1=YEAST-L & H=LISTSERV.ICORS.ORG

It has been going for years and the people their are very knowledgeable

about yeast. They can tell you about diet and environment and have

people that have young children that have fought this problem.

This list used to be the one at maelstrom. stjohns.edu they just changed

servers.

Tara Belderok wrote:

>I know this is a little off the subject line, but I'm wondering if anyone

>can tell me how I can rid of Candida in our home. We all have it. Not sure

>about my 8 week old, but he's probably well on his way. We need to do

>something proactive NOW!!! HELP!!!

>

>Tara Belderok

>

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Hi Tara,

I am having great success with a product called Yeast Away

(http://peakhealthcareproducts.com/) Ph: 1-866-442-0617.

I ended up with a serious case of systemic candida 25 years ago when I was

under heavy physical and emotional strain and had to take a very strong

antibiotic. I spent over $5000. in the first 2 or 3 years trying everything

available then. I did a 10-day wheat grass fast and 1 1/2 years of the

strict candida diet all to no avail. So I basically gave up on it until

this last year when I started having blood sugar and urinary problems. I

have been on Yeast Away for about 9 weeks now and all the symptoms seem to

be gone. I am itch free for the first time in 25 years and all the other

symptoms seem to be gone as well. And what I like the most about it is that

there is no die-off and no special diet is required. Just take the capsules

every day until the yeast is gone. The product is just a very strong

probiotic plus cellulase. The cellulase breaks through the cell wall of the

yeast killing it in a way that does not leave a toxic load behind as most

anti-fungals do.

Good luck,

At 09:53 AM 12/8/2006, you wrote:

>I know this is a little off the subject line, but I'm wondering if anyone

>can tell me how I can rid of Candida in our home. We all have it. Not sure

>about my 8 week old, but he's probably well on his way. We need to do

>something proactive NOW!!! HELP!!!

>

>Tara Belderok

>

>

>

>Internal Virus Database is out-of-date.

>Checked by AVG Anti-Virus.

>Version: 7.1.409 / Virus Database: 268.14.18 - Release Date: 11/27/2006

----------

----------

Internal Virus Database is out-of-date.

Checked by AVG Anti-Virus.

Version: 7.1.409 / Virus Database: 268.14.18 - Release Date: 11/27/2006

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Hi ,

I will start to take a look at it with my clients. This is one of those

situations where I get to learn by your sacrifice and suffering. Thank you. If

it works as well for others I will get to look good. Oh well, it is a dirty job

but something has to do it. -Dave

----- Original Message -----

From: Moeck<mailto:dmoeck@...>

gallstones <mailto:gallstones >

Sent: Friday, December 08, 2006 3:47 PM

Subject: Re: Candida

Hi Dave,

Thank you. I have kept your words in mind over the past 2 months, wondering

if I was spending too much for it. All I know is it seems to have been more

effective than anything else I ever tried and I haven't even used $100.

worth of it yet. It seems to be a no stress slow and steady type of

approach to candida. I am hoping that means that it is also thorough and

lasting.

At 04:24 PM 12/8/2006, you wrote:

>Good to here you are doing well on the cellulase , thanks, -D

>----- Original Message -----

>From: Moeck<mailto:dmoeck@...<mailto:dmoeck@...>>

>To:

><mailto:gallstones%40>gallstones <mailto:gallston\

es ><mailto:gallstones <mailto:gallstones@gro\

ups.com>>

>

>Sent: Friday, December 08, 2006 12:09 PM

>Subject: Re: Candida

>

>Hi Tara,

>

>I am having great success with a product called Yeast Away

>(<http://peakhealthcareproducts.com/<http://peakhealthcareproducts.com/>>http:/\

/peakhealthcareproducts.com/<http://peakhealthcareproducts.com/><http://peakheal\

thcareproducts.com/<http://peakhealthcareproducts.com/>>)

>Ph: 1-866-442-0617.

>

>I ended up with a serious case of systemic candida 25 years ago when I was

>under heavy physical and emotional strain and had to take a very strong

>antibiotic. I spent over $5000. in the first 2 or 3 years trying everything

>available then. I did a 10-day wheat grass fast and 1 1/2 years of the

>strict candida diet all to no avail. So I basically gave up on it until

>this last year when I started having blood sugar and urinary problems. I

>have been on Yeast Away for about 9 weeks now and all the symptoms seem to

>be gone. I am itch free for the first time in 25 years and all the other

>symptoms seem to be gone as well. And what I like the most about it is that

>there is no die-off and no special diet is required. Just take the capsules

>every day until the yeast is gone. The product is just a very strong

>probiotic plus cellulase. The cellulase breaks through the cell wall of the

>yeast killing it in a way that does not leave a toxic load behind as most

>anti-fungals do.

>

>Good luck,

>

>

>At 09:53 AM 12/8/2006, you wrote:

>

> >I know this is a little off the subject line, but I'm wondering if anyone

> >can tell me how I can rid of Candida in our home. We all have it. Not sure

> >about my 8 week old, but he's probably well on his way. We need to do

> >something proactive NOW!!! HELP!!!

> >

> >Tara Belderok

> >

> >

> >

> >Internal Virus Database is out-of-date.

> >Checked by AVG Anti-Virus.

> >Version: 7.1.409 / Virus Database: 268.14.18 - Release Date: 11/27/2006

>

>----------

>

>----------

>

>Internal Virus Database is out-of-date.

>Checked by AVG Anti-Virus.

>Version: 7.1.409 / Virus Database: 268.14.18 - Release Date: 11/27/2006

>

>

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